Don't Waste Your Money

Horny Goat Weed

What To Avoid

Adults

Grade D — Poor Evidence Grade

MOOP's Take

The mechanism (icariin → PDE5 inhibition) is theoretically interesting but the oral bioavailability is terrible. The active compound doesn't survive digestion well enough to produce meaningful systemic effects at normal doses.

⚠️ Why I Don't Recommend This

Poor oral bioavailability — the active compound doesn't survive digestion at normal doses. The mechanism is interesting in theory; the delivery doesn't work.

💪 Coach Arnie

If the mechanism requires the compound to survive digestion and get into your bloodstream, and it doesn't, it's a placebo. Move on.

🩺 Doc Hartley

In vitro data is interesting. Human RCTs are lacking and the existing studies are low quality. Bioavailability of icariin from oral supplementation appears insufficient for clinically meaningful PDE5 inhibition. Not recommended.

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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before starting any new supplement regimen.
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